• During these processes meiotic recombination plays a critica

  2020-10-20

  

  During these processes, meiotic recombination plays a critical role by physically associating homologs and ensures accurate chromosome segregation. In addition, meiotic recombination redistributes genetic material between homologs, resulting in haplotype diversity among progeny, impacting ecological

• We next examined the effects of

  2020-10-20

  

  We next examined the effects of substituents around the carboxylic Cholera Toxin moiety on CRTH2 binding (Table 4). The carboxylic acid moiety shared by the representative CRTH2 antagonists and is essential for the CRTH2 activity. Germinal dimethylation of the methylene moiety next to the carboxyli

• br Materials and methods br Results br Discussion

  2020-10-20

  

  Materials and methods Results Discussion Taken together with our previous report, our current data demonstrate induction of Chk in monocytes by IL-3, IL-4, IL-13, and GM-CSF ((Musso et al., 1994) and Fig. 1, Fig. 2, Fig. 3, Fig. 4). Chk interleukin is also inducible by stem cell factor or

• In this paper we focused on Ewing sarcoma

  2020-10-20

  

  In this paper, we focused on Ewing sarcoma (ES), a rapidly growing, highly malignant bone tumor developing metastases in the vast majority of patients unless multiagent chemotherapy is applied [16]. ES is the second most frequent bone tumor in childhood and adolescence, and is characterized by the p

• br Experimental section br Acknowledgments MIN cells were ki

  2020-10-20

  

  Experimental section Acknowledgments MIN6 cells were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.), SENTAN

• Our results demonstrated that ET a

  2020-10-20

  

  Our results demonstrated that ET-1, a Wnt ligand, stimulated the Wnt/β-catenin signaling pathway. First, ET-1/ETRA binds to Frizzled family cell-surface receptors, resulting in the activation of Dvl1, a Dishevelled (DSH) family protein. Next, activated DSH inhibits the Axin, GSK-3β, and APC protein

• In mammals NETs contain DNA

  2020-10-20

  

  In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48]. In fish, NETs-like structures have been observed, and DNA staining and immuno

• Similarly in the EAE model Chalmin

  2020-10-20

  

  Similarly in the EAE model, Chalmin et al. previously demonstrated that EBI2 and CH25H might be responsible for the efficient egress of differentiated Th17 cells from the draining lymph nodes [31]. As discussed above, in active EAE we did not find differences in EAE development and only the transfer

• Just as Dorin et al and Nguyen et al

  2020-10-19

  

  Just as Dorin et al. [2] and Nguyen et al. [3] write in regard to their models, our static model can be used to estimate the affinities of Hydrochlorothiazide to albumin and CBG. Dorin et al. [2] estimates the K, but not K, since they find that their model is not particular sensitive towards change

• br Experimental Procedures br Author Contributions

  2020-10-19

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility CBL0137 hydrochloride have been identified in many of these regions [2]. How these genes e

• The strand domain swap in

  2020-10-19

  

  The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2

• br Experimental Procedure br Acknowledgment This work was su

  2020-10-19

  

  Experimental Procedure Acknowledgment This work was supported by Ministry of Education, Singapore (MoE Tier-2) grant (R-154-000-625-112) and R154-000-A72-114 (AcRF Tier 1 grant) respectively. We acknowledge the Advanced Photon Source Beamline 24-ID-C, Argonne National Laboratory, USA. D.N. is

• A role for the E E interface in governing mono

  2020-10-19

  

  A role for the E2–E3 interface in governing mono- versus polyubiquitination is not mutually exclusive with that of the E2 backside, which has previously been shown to mediate polyubiquitination through its ability to bind to Ub [21], [25], [33]. Brzovic and colleagues first demonstrated the importan

• br Introduction The ubiquitination status of

  2020-10-19

  

  Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of proteins in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechanover,

• Twin studies have shown that P

  2020-10-17

  

  Twin studies have shown that P has moderate heritability. Zuckerman (1989) reviewed the earlier studies of P or related traits and found a median heritability of 0.51. However, twin studies using an Eysenckian P scale have tended to estimate somewhat lower heritabilities than this, in the range 0.36

15856 records 802/1058 page Previous Next First page 上5页 801802803804805 下5页 Last page