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Compounds and were tested for pharmacodynamic effects in a
2021-09-02
Compounds , and were tested for pharmacodynamic effects in a mouse oral glucose tolerance test (oGTT) in wild-type and GPR120 deficient mice, and each compound demonstrated GPR120 mechanism-based effects. Data for compound is shown in , indicating mechanism-based reduction in glucose excursion a
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GPR A a G protein coupled
2021-09-02
GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic survivin (baculoviral IAP repeat-containing protein 5) (21-28) receptor [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it
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An increased sympathetic tone and the hormone glucagon are t
2021-09-02
An increased sympathetic tone and the hormone glucagon are the main glucose mobilizing factors [28], [29]. Single-cell transcriptome analysis of human islet cells suggests the expression of Ffar1 not only in β-cells but also in α-cells [30]. Moreover, analysis of rat α-cells indicates that FFAR1 exp
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br Acknowledgements br Introduction Benzodiazepine BZ treatm
2021-09-02
Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd
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Capreomycin Sulfate Fig A demonstrates the body weight
2021-09-02
Fig. 2A demonstrates the body weight gain of the pregestational females. High-fat diet in wild-type mice increased body weight in 2 weeks and sustained this increase over 8 weeks. A similar effect was noted in glut3 mice in response to a high-fat diet. Fig. 2B depicts fat and muscle mass as assessed
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The translation of our rat findings to bovine and
2021-09-02
The translation of our rat findings to bovine and human lenses revealed that the expression of glucose transporters was more straightforward in bovine and human than in the rat lens, since only GLUT1 was detected in these lenses. Using the C-terminal GLUT1 antibody, we observed bands for GLUT1 in al
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The waiting time for first arrival of cells into
2021-09-02
The waiting time for first arrival of leukotriene receptor antagonist into the dense fraction of 3–4 min at the normal chloride conductance, and about 30 min with inhibition to about 10% of the normal value, signifies that the Gardos channels in the activated cells become maximally or near maximall
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The subcellular redistribution of some metabolic enzymes is
2021-09-02
The subcellular redistribution of some metabolic enzymes is dynamic and responsive to metabolic conditions. In the absence of glucose, Glucokinase (GK) is bound to its regulatory protein in the nucleus of the hepatocyte and translocates to the cytoplasm when sugar levels increase [12]. Muscle glycog
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However T DM and associated
2021-09-02
However, T1DM and associated hyperglycemia can adversely affect the structure and function of the heart in several mechanisms including inhibiting the anabolic effect of insulin due to its deficiency, generation of higher levels of ROS and induction of lipid peroxidation, and subsequent activation o
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Compounds that induce exocytosis in cultured cells include C
2021-09-02
Compounds that induce exocytosis in cultured 5-Methoxy-CTP include Ca2+-dependent [14] or Ca2+-independent [15] mechanisms. Ca2+-dependent exocytosis releases soluble enzyme content from lysosomes [16] operating by increasing the cytosolic concentration of Ca2+[13] by recruiting extracellular Ca2+[
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Given the fact that most criticism on genetic association
2021-09-02
Given the fact that most criticism on genetic association studies is the lack of replicability (Hirschhorn, Lohmueller, Byrne, & Hirschhorn, 2002), the aim of the present study is to investigate the influence of the DBH polymorphism rs1611115 (C-970T) on RD in two independent samples of healthy part
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One of the most frequent
2021-09-01
One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are Cyclophosphamide regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respect
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Many filarial species harbor an
2021-09-01
Many filarial species harbor an endosymbiotic bacterium of the genus Wolbachia. A recent investigation of Wolbachia distribution in 35 filarial species including 28 species and 7 genera and/or subgenera have shown that 37% of them harbor Wolbachia (Ferri et al., 2011). In filarial nematodes, Wolbach
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AQP protein expression was determined by Western blot analys
2021-09-01
AQP4 protein expression was determined by Western blot analysis. Briefly, protein samples (50μg) from brains or astrocytes were separated by 12% SDS–polyacrylamide gel electrophoresis and transferred to nitrocellulose membranes. The membranes were reacted with a rabbit polyclonal antibody against AQ
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br Conflicts of interest br Acknowledgements This work was s
2021-09-01
Conflicts of interest Acknowledgements This work was supported by funding from Young Sanjin Scholars Distinguished Professor, the Aid Program for Innovation Research Team in Shanxi Agricultural University (CXTD201201), and the Special Fund for Agro-scientific Research in the Public Interest of
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