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br Findings br Discussion br Conclusions Midwives were more
2023-10-26
Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea
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Previous studies demonstrate that chiral biointerface has gr
2023-10-26
Previous studies demonstrate that chiral biointerface has great influence on cells adhesion and proteins adsorption [39], [40], [41], [42], [43], which inspired us to further develop antimicrobial materials or surfaces by taking advantage of the “chiral taste” of microbes. L-borneol is a hydrophobic
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The chronic induction of skeletal
2023-10-26
The chronic induction of skeletal muscle AMPK activity is an attractive therapeutic approach for DMD, as it addresses multiple cellular pathways needed for powerful phenotypic plasticity, including activation of the slow oxidative myofiber program, corrective autophagic signaling, as well as regulat
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Interestingly we noticed that LPS exposure was
2023-10-26
Interestingly, we noticed that LPS exposure was associated with decreased phosphorylation of AMPK and increased phosphorylation of p70S6K1, suggesting that AMPK inactivation and the subsequent mTOR activation might be involved in the development of LPS-induced inflammation. On the other side, treatm
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In order to get a better understanding of
2023-10-26
In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of actin polymerization inhibitor with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. W
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The enzyme plays an important role
2023-10-26
The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host 20 hydroxyecdysone mg for its purine requirements and survival (Perrotto
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Similarly Dilma et al tried
2023-10-26
Similarly Dilmaç et al. [16] tried to assess the diagnostic value of adenosine deaminase activity in sputum of patients with pulmonary tuberculosis, their aim was to determine and compare sputum ADA activity in pulmonary tuberculosis, lung cancer and chronic obstructive pulmonary disease (COPD) pati
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AdK as an important upstream regulator of adenosine based
2023-10-26
AdK as an important upstream regulator of adenosine-based homeostasis represents a promising drug target since it leads to an increase in adenosine concentrations. Taking into account that the adenosine formation is only increased in affected tissues under stress with high adenosine levels, AdK inhi
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Genetic observations from these studies suggest that GMF reg
2023-10-26
Genetic observations from these studies suggest that GMF regulates Arp2/3 complex and pexidartinib dynamics in vivo13, 14. Budding yeast Gmf1 localizes to cortical actin patches, sites of endocytosis assembled by Arp2/3 13, 14. Furthermore, deletion of GMF1 exacerbates the growth defects of a cof1-
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There has been growing interest over computational methods t
2023-10-26
There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it SCH772984 HCl has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSA
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br Experimental Procedures br Acknowledgments
2023-10-26
Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmit
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APP is a member of a conserved protein
2023-10-25
APP is a member of a conserved protein family that also includes amyloid precursor-like proteins 1 and 2 (APLP1, APLP2).8, 9, 10 The proteins in this family are type I single-pass transmembrane NPI-0052 with receptor-like structural features but not entirely clear cellular functions.11, 12, 13, 14
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Calmidazolium chloride A Venn diagram representing RNA
2023-10-25
A. Venn diagram representing RNA-seq data that show the number of gene overlaps in GFP and HepKO livers after chronic PF-06409577 dosing. B. Top canonical pathways that changed according to Ingenuity Pathway Analysis after chronic PF-06409577 dosing. C. Fibrosis-related genes that were altered in GF
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Introduction Induction of long term potentiation LTP
2023-10-25
Introduction Induction of long-term potentiation (LTP), the cellular correlate of learning and memory, triggers profound changes in the structure and function of excitatory synapses by increasing dendritic spine size and synaptic strength. Significant progress has been made in understanding the int
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An issue related to research without biomarkers is that many
2023-10-25
An issue related to research without biomarkers is that many studies will ascertain some but not all biomarker groups in study participants. Because tau PET is relatively new, incomplete biomarker information will occur in studies that use imaging for amyloid and neurodegenerative biomarker characte
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